Keep a Truck Vault in the pickup and passenger vehicle when I need to take them with me. They are my responsibility so they are either on my person or in the vault when away from home.
Have a truck vault under the bed for handgun and shotgun, welded to the steel beam of the house in the basement, one in the barn for the extras. Around here the big safes surprisingly don’t always stop someone – they’ll steal the darn things when no one home. Lots of people around here have a long commute and are gone for hours.